Acute Stroke Clinical Trial
Official title:
A Pilot Study Assessing the Safety and Feasibility of Remote Ischemic Conditioning Paired With Endovascular Treatment for Acute Ischemic Stroke
Currently, early reperfusion is considered as the most effective therapy for the treatment of
acute ischemic stroke (AIS). Over the past 20 years, intravenous tissue plasminogen activator
(IV tPA) has been demonstrated to be the only effective therapy for AIS. More recently,
several large randomized clinical trials have concluded the superiority of endovascular
mechanical thrombectomy for AIS. Furthermore, with the development of materials and
techniques, the occluded artery can be recanalized with high percentage (60%-90%), and the
rate of recanalization is still being improved. A great number of AIS patients are now
eligible for revascularization therapy and there should be a good prognosis of AIS after
recanalizing the occluded artery using mechanical thrombectomy. However, things are never as
simple as wished to be. The rate of patients with functional independence is less than 50%
and over 15% patients died at 3 months post thrombectomy. The discrepancy between the
functional outcome and recanalization rates encourage researchers to explore strategies that
further improving the functional outcome of AIS patients.
Remote ischemic conditioning has been demonstrated to reduce cerebral infarct size in mouse
model of focal cerebral ischemia. And clinical researches demonstrated the protective effects
of remote ischemic conditioning in AIS patient treated with IV tPA,. However, whether remote
ischemic conditioning is safe and effective in protecting patients with large-vessel ischemic
stroke and undergoing endovascular treatment is still unknown.
In the present study, the investigators will assess the safety and feasibility of remote ischemic condition paired with endovascular treatment for AIS. A single arm of AIS patients treated with endovascular therapy will be recruited, and remote ischemic conditioning will be applied prior to reperfusion therapy and in combination with post reperfusion therapy. ;
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