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Impact of Neutrophil Activation in Acute Ischemic Stroke Patients Treated With Endovascular Therapy — NEUTROSTROKE  

Acute Stroke Clinical Trial

Official title:
Neutrophil Activation in Acute Ischemic Stroke Patients Treated With Endovascular Therapy

Clinical Trial Summary

Clinical and experimental data suggest that neutrophil activation and extravasation are deleterious in acute ischemic stroke (AIS) involving an increased risk of unfavorable outcome and hemorrhagic transformation (HT). However, clinical trials targeting neutrophil recruitment in AIS patients were negative. Recently, an experimental study has shown that neutrophil activation and transmigration begin immediately after the occlusion. Inhibition of neutrophil recruitment several hours after the start of ischemia appears therefore too late to have a clinical relevance. The objective is to study the time dependent impact of neutrophils in AIS and the predominant mediators in each time point to identify the appropriate therapeutic target and time window.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02900833
Study type Observational
Source Fondation Ophtalmologique Adolphe de Rothschild
Contact
Status Active, not recruiting
Phase
Start date March 24, 2016
Completion date August 31, 2024
View Details
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