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Clinical Trial Details — Status: Withdrawn

Administrative data

NCT number NCT02907736
Other study ID # JDS_2015_45
Secondary ID
Status Withdrawn
Phase
First received September 6, 2016
Last updated March 16, 2018
Start date November 12, 2015
Est. completion date July 1, 2017

Study information

Verified date March 2018
Source Fondation Ophtalmologique Adolphe de Rothschild
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Acute Ischemic stroke (AIS) remains a leading cause of adult disability, cognitive impairment and mortality worldwide despite the development of revascularization therapies (intravenous Tissue Plasminogen Activator (t-PA) and endovascular therapy). Thrombosis resistance after IV t-PA therapy is frequent especially in case of AIS with proximal occlusion. In recent years, neutrophil extracellular traps (NETs) have been identified as major triggers and structural factors of various forms of thrombosis. NETs are extracellular webs primarily composed of DNA from neutrophils. A recent study shows that the NETs burden in coronary thrombi is positively correlated with the infarct size and negatively correlated with electrocardiogram (ST-segment) resolution. This later study revealed that in vitro addition of DNase I accelerated the t-PA-induced thrombolysis of coronary thrombi. NETs could, in consequence, be promising targets for improved thrombolysis in AIS.

The aim of this study is to assess the impact of NETs composition of thrombi retrieved during endovascular therapy in AIS patients on IV t-PA induced thrombolysis, clinical outcome and AIS etiologies.


Recruitment information / eligibility

Status Withdrawn
Enrollment 0
Est. completion date July 1, 2017
Est. primary completion date July 1, 2017
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- age > 18 years old

- AIS secondary to a large vessel occlusion

- admitted for endovascular therapy.

Exclusion Criteria:

- Pregnant or breast feeding patient patient under legal protection

- Patient opposition to participate in this study

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
France Fondation Ophtalmologique Adolphe de Rothschild Paris

Sponsors (1)

Lead Sponsor Collaborator
Fondation Ophtalmologique Adolphe de Rothschild

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary thrombus origin according to the etiology of the stroke (TOAST classification) baseline
Primary red cells counts quantitative assessment of the relative fractions of the main constituents after Hematoxylin and Eosin staining : baseline
Primary white cells counts quantitative assessment of the relative fractions of the main constituents after Hematoxylin and Eosin staining baseline
Primary platlet counts quantitative assessment of the relative fractions of the main constituents after Hematoxylin and Eosin staining baseline
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