Acute Stroke Clinical Trial
Official title:
The Effect of a Ketogenic Diet on Blood Glucose, Function and Disease Progress in Acute Stroke Patients
The purpose of this controlled, randomized intervention is to investigate whether a
fat-based (ketogenic) diet given for a week has a positive effect on blood sugar, mortality
and function in patients hospitalized with acute stroke compared to the effect of a usual
diet.
The study hypothesis is that a ketogenic diet and reduced availability of glucose to the
brain cells will reduce the volume of neuronal damage in the brain and improve function.
The intervention will take place at the neurological units of Glostrup and Bispebjerg
Hospital in Denmark.
A ketogenic diet can induce ketosis after a period of 2-3 days and offer the brain an
alternative energy substrate to glucose in the form of ketone bodies. Feeding the brain
ketone bodies can potentially benefit a stroke patient's brain in several ways:
Stroke is characterized by impaired blood and oxygen supply to brain cells. This can cause
glucose to convert to lactate which is toxic for the brain. Decreasing glucose availability
to brain cells may thus potentially decrease the area of damage in the ischemic penumbra
(perifephery of the stroke). Compared with sugar, burning ketone bodies requires less oxygen
to produce the same amount of energy, suggesting that brain cells could have a potential
greater chance of surviving during circumstances of reduced oxygen supply. By decreasing
mitochondria activity, ROS synthesis is also decreased, which can help decrease the necrotic
area around the ischemic penumbra. Furthermore, the ketogenic diet does not induce an
increase in blood sugar which could be an advantage since many stroke patients are admitted
with hyperglycemia associated with a worse outcome.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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