Acute Myocardial Infarction Clinical Trial
— MIRON-STRAINOfficial title:
Wall Strain Index Ratio as a Biomarker for Mechanical Complication of Hemorrhagic MI
NCT number | NCT06450912 |
Other study ID # | 19978e |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | June 1, 2022 |
Est. completion date | June 1, 2024 |
Verified date | June 2024 |
Source | Indiana University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Hemorrhagic Myocardial infarctions are at high risk for mechanical complications including cardiac rupture. Prediction of vulnerable myocardial segments is an important step for the stratification of hemorrhagic MI patients. Wall motion index ratio is an important parameter to determine regions of high vulnerability within the 17-segment LV model of hemorrhagic MI.
Status | Completed |
Enrollment | 250 |
Est. completion date | June 1, 2024 |
Est. primary completion date | June 1, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Index STEMI - Primary PCI - Able to complete Cardiac MR - STRAIN Protocol Exclusion Criteria: - Contraindication to CMR (Contrast Hypersensitivity, Metallic Implants, Abnormal Rhythms, breathing difficulties) |
Country | Name | City | State |
---|---|---|---|
United States | Krannert Cardiovascular Research Center, Indiana University School of Medicine | Indianapolis | Indiana |
Lead Sponsor | Collaborator |
---|---|
Rohan Dharmakumar |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Wall Strain Index for Potential Detection of Intramyocardial Hemorrhage | Difference in Wall Strain Index values between patients with intramyocardial hemorrhage and those without, confirmed by cardiac MRI. | 48 hours Post-PCI | |
Primary | Wall Strain Index in Detecting the Severity of Intramyocardial Hemorrhage | Relationship between initial Wall Strain Index measurements and the volume of intramyocardial hemorrhage quantified by cardiac MRI | 48 hours Post-PCI | |
Primary | Wall Strain Index Ratio in Identification of Vulnerable LV Segments for Cardiac Rupture | Wall Strain Index Ratio for circumferential and longitudinal strain in identifying vulnerable hemorrhagic left ventricular segments at risk for rupture | 48 hours Post-PCI |
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