Acute Myocardial Infarction Clinical Trial
Official title:
A Pharmacokinetic and Pharmacodynamic Study Comparing Metoprolol IR and Metoprolol CR/XL Subsequent to Initial Treatment With Intravenous and/or Oral Metoprolol in Patients With Suspected Acut Myocardial Infarction
The objective of the study was to compare treatment with two different oral formulations of
metoprolol, metoprolol immediate release (IR) and metoprolol extended release (CR/XL) in
patients with acute myocardial infarction regarding the following:
Pharmacokinetics, peak and trough plasma concentrations and area under the plasma
concentration curve.
Pharmacodynamics, hourly means of Holter recorded heart rate. Tolerability. An open,
randomised design with two parallel groups was employed.
A pharmacokinetic and pharmacodynamic study comparing metoprolol IR and metoprolol CR/XL subsequent to initial treatment with intravenous and/or oral metoprolol in patients with suspected acut myocardial infarction ;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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