Strain-Encoded Magnetic Resonance Imaging in Acute Myocardial Infarction

Acute Myocardial Infarction Clinical Trial

— 137-2005  

Official title:

Strain-Encoded Magnetic Resonance Imaging for Evaluation of Left Ventricular Function and Acute Myocardial Infarction

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00752713
• Other study ID #: SENC in AMI
• Status: Completed
• Phase: N/A
• First received: September 11, 2008
• Last updated: September 15, 2008
• Start date: January 2007
• Est. completion date: January 2008

Study information

• Verified date: September 2008
• Source: RWTH Aachen University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Federal Institute for Drugs and Medical Devices
• Study type: Observational

Clinical Trial Summary

The aim of the study was therefore to evaluate whether myocardial deformation imaging performed by SENC allows for quantification of regional left ventricular function and is related to transmurality states of infarcted tissue in patients with acute myocardial infarction (AMI).

Description:

CMR was performed in 38 consecutive patients with AMI 3±1 days after successful reperfusion using a clinical 1.5 Tesla MR-scanner. Ten healthy volunteers served as controls. SENC is a technique that directly measures peak circumferential strain from long-axis views and peak longitudinal strain from short axis views. Measurements were obtained for each segment in a modified 17 segment model. Wall motion and infarcted tissue were evaluated semi-quantitatively from SSFP cine sequences and contrast-enhanced-MR-images and were then related to myocardial strain. Comparison of peak circumferential strain assessed by SENC and MR-tagging was performed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 48
• Est. completion date: January 2008
• Est. primary completion date: January 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 30 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients with AMI after successful reperfusion

• Healthy volunteers in control group

Exclusion Criteria:

• No reperfusion

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Acute Myocardial Infarction
• Infarction
• Myocardial Infarction

Intervention

Procedure:
• cardiac MRI
cardiac MRI at one time point for group 1 after intervention for group 2 at any time point

Locations

Country	Name	City	State
Germany	University Hospital Heidelberg	Heidelberg

Sponsors (2)

Lead Sponsor	Collaborator
RWTH Aachen University	Heidelberg University

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Left ventricular function		01.01.2007 until 01.02.2007	No
Secondary	Transmurality		01.01.2007 until 01.02.2007	No