Acute Myocardial Infarction Clinical Trial
Official title:
Non-invasive Evaluation of Coronary Pathology by Transthoracic Doppler Echocardiography. A Comparative Study to Coronary Angiography.
Non-invasive evaluation of patients with stable angina and unstable coronary syndromes with transthoracic Doppler echocardiography to evaluate presence of significant coronary stenoses. Blinded evaluation and comparison with coronary angiography: presence and location of stenoses, and head to head comparison of clinical value and patient classification.
Transthoracic Doppler echocardiographic evaluation with extensive evaluation of coronary
stenoses in all 3 main branches using colour flow, pulsed Doppler and Coronary flow velocity
reserve (CFVR)after pharmacologic stress with adenosin in the area of LAD and RDP. Blinded
evaluation of Doppler results and coronary angiography regarding the other examination
modality. Coronary angiography diagnostic "gold standard". Only stable and unstable patients
otherwise scheduled for angiography on clinical reasons will be examined and included in the
study.
Added January 2007 after ethics committee approval: comparison of CFVR with invasive
fractional flow reserve (FFR) in selected subset of patients.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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