Acute Myocardial Infarction Clinical Trial
Official title:
Bone Marrow Stimulation With G-CSF in Acute Myocardial Infarction,
The purpose of this trial is to investigate the effect of treatment with granulocyte-colony stimulating factor (G-CSF) bone marrow stimulation on circulating stem cells' ability to develop new blood vessels in the myocardium after an acute myocardial infarction.
Intracoronary infusion of bone-marrow stem cells after a ST elevation myocardial infarction
(STEMI) seems to improve cardiac function. An alternative strategy is increase of
circulating stem cells by mobilisation from the bone marrow with Granulocyte-Colony
Stimulating Factor (G-CSF).
Objective: To determine the short-term (30 days) safety of G-CSF therapy after a STEMI
treated with acute percutaneous coronary intervention (PCI).
Methods: Patients with STEMI treated with PCI <12 hours after symptom onset were randomised
(1:1) to G-CSF (10 μg/kg/d) or placebo for 6 days in a double-blind design. Other inclusion
criteria: age 20-70 years, culprit lesion in a large coronary artery, and peak CKMB >100
microgram/L. Follow-up was done after 1, 5 and 6 months, with an angiogram at 5 months.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind
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