Acute Myeloid Leukemia Clinical Trial
Official title:
Phase 1 Study Evaluating the Tolerance and Biologic Activity of Oral Ciclopirox Olamine in Patients With Relapsed or Refractory Hematologic Malignancy
This is an open-label, single arm study. Approximately 3-30 patients will be enrolled.
Patients will receive Oral ciclopirox olamine (aqueous suspension), initial starting dose of
5 mg/m2/day administered as a single dose daily for 5 days. Three patients will initially be
treated at each dose level in sequential cohorts. Dose escalation will continue for each
subsequent cohort based on toxicity and plasma drug concentrations observed during the
previous cohort. Dose escalation will continue until establishment of the maximum tolerated
dose (MTD) has been met.
Patients who have demonstrated response to treatment, up to 6 total cycles of treatment may
be administered. If additional cycles are warranted, ciclopirox olamine will be given at the
same dose and frequency as the patient initially received.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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