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NCT00159003 Clinical Trial

Analysis of Genetic Factors Related to Predisposition and Prognosis of Hematological Malignancies in Israel

Acute Myeloid Leukemia Clinical Trial

Official title:
Molecular Analysis of Genetic Elements Which May Influence Predisposition and Prognosis of Hematological Malignancies in Different Ethnic Groups in Israel

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00159003
Other study ID # 132910-HMO-CTIL
Secondary ID
Status Completed
Phase N/A
First received September 8, 2005
Last updated August 9, 2017
Start date January 1, 1998
Est. completion date July 1, 2017

Study information
Verified date August 2017
Source Hadassah Medical Organization
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

There are naturally occuring variations in the genetic makeup of all of us. Some of these variations may contribute to a change in susceptibility toward different diseases or change the prognosis.

We are studying these genetic variations in patients with leukemia. The genes we are studying are those which influence detoxification of drugs and toxins.

Description:

We have prepared DNA on patients with leukemia (AML, CML and CLL) and we are studying the influence of polymorphisms in drug metabolism and disposition genes on predisposition and prognosis of these types of leukemia. The genes we are studying include: MDR1, CYP3A4, NQO1, NAT1/2, GST, hOCT. We plan to study other genes that may be contributory.

Study includes comparing the frequency of polymorphisms in these genes with the frequency in the general population and the study of DNA biding proteins which bind at the sites of these polymorphisms.

Recruitment information / eligibility
Status Completed
Enrollment 100
Est. completion date July 1, 2017
Est. primary completion date July 1, 2017
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- diagnosis of acute myeloid leukemia or chronic lymphocytic leukemia

Exclusion Criteria:

- under 18 years of age

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Israel Hadassah Medical Organization Jerusalem

Sponsors (1)
Lead Sponsor Collaborator
Deborah Rund

Country where clinical trial is conducted

Israel, 

References & Publications (1)

Chanock S. Genetic variation and hematology: single-nucleotide polymorphisms, haplotypes, and complex disease. Semin Hematol. 2003 Oct;40(4):321-8. Review. — View Citation

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