Acute Myeloid Leukemia Clinical Trial
Official title:
Molecular Analysis of Genetic Elements Which May Influence Predisposition and Prognosis of Hematological Malignancies in Different Ethnic Groups in Israel
There are naturally occuring variations in the genetic makeup of all of us. Some of these
variations may contribute to a change in susceptibility toward different diseases or change
the prognosis.
We are studying these genetic variations in patients with leukemia. The genes we are studying
are those which influence detoxification of drugs and toxins.
We have prepared DNA on patients with leukemia (AML, CML and CLL) and we are studying the
influence of polymorphisms in drug metabolism and disposition genes on predisposition and
prognosis of these types of leukemia. The genes we are studying include: MDR1, CYP3A4, NQO1,
NAT1/2, GST, hOCT. We plan to study other genes that may be contributory.
Study includes comparing the frequency of polymorphisms in these genes with the frequency in
the general population and the study of DNA biding proteins which bind at the sites of these
polymorphisms.
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