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Clinical Trial Summary

The goal of this study is to determine the safety and antitumor effects of REM-422, a MYB mRNA degrader, in people with Higher Risk MDS and relapsed/refractory AML


Clinical Trial Description

This is a Phase 1, open-label, non-randomized, multicenter study investigating REM-422, a potent, selective, and oral small molecule mRNA degrader that reduces expression of the MYB transcription factor for patients with higher risk MDS or relapsed/refractory AML. This study includes a Dose Escalation Phase and a Dose Expansion Phase. The purpose of the Dose Escalation Phase is to determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of REM-422 in patients with higher risk MDS or relapsed/refractory AML. The purpose of Dose Expansion is to further evaluate the safety and anti-tumor activity of the RP2D carried forward from Dose Escalation. Participation in this study will continue until disease progression, therapy intolerance, or participant withdrawal. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06297941
Study type Interventional
Source Remix Therapeutics
Contact Barb Geiger, BSN
Phone 913-206-2798
Email bgeiger@remixtx.com
Status Recruiting
Phase Phase 1
Start date April 26, 2024
Completion date June 15, 2027

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