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Clinical Trial Summary

This study is a single-arm, open-label, dose-escalating + dose-expansion clinical study, aiming to evaluate the safety and efficacy of targeting CD123 CAR-NK cell preparations in Relapsed/refractory acute myeloid leukemia (AML) or blastocytic plasmacytoid dendritic cell neoplasm (BPDCN). The pharmacokinetic characteristics of CAR-NK cell preparations for the treatment of patients with Relapsed/refractory acute myeloid leukemia or blastocytic plasmacytoid dendritic cell neoplasm were obtained and the recommended dose.


Clinical Trial Description

According to the different disease type, it is divided into two subgroups: AML and BPDCN. Each subgroup includes a dose exploration stage (Part A) and a dose expansion stage (Part B). 3 patients were explored, starting from the low-dose group, and in the dose expansion phase, the safety and efficacy were further verified according to the safe recommended dose obtained in the dose exploration phase. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06006403
Study type Interventional
Source Chongqing Precision Biotech Co., Ltd
Contact Jia Wei, M.D
Phone 13986102084
Email jiawei@tjh.tjmu.edu.cn
Status Recruiting
Phase Phase 1/Phase 2
Start date August 31, 2023
Completion date August 31, 2026

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