Acute Myeloid Leukemia Clinical Trial
Official title:
A Phase II Study of CLAG Regimen in Combination With Imatinib Mesylate (Gleevec) in Refractory or Relapsed Acute Myeloid Leukemia
The purpose of this study is to evaluate the safety of combined chemotherapy treatment (CLAG regimen) with Imatinib Mesylate (Gleevec) in patients with AML.
In relapsed or resistant acute myeloid leukemia (type of blood cancer where immature blood
cells are increased, blocking normal blood cells production) no standard therapy exits.
Response rates are similar for different chemotherapy treatments. Allogenic stem cell
transplant remains the only curative option
The purpose of this study is to evaluate the safety of combined chemotherapy treatment (CLAG
regimen) with Imatinib Mesylate (Gleevec). The CLAG regimen is a combination of the
chemotherapy drugs cladribine and cytarabine, as well as, neupogen which increases the white
blood counts.
Imatinib Mesylate is believed to work by interfering with the abnormal protein by blocking
it from telling the body to keep making more and more abnormal white blood cells. Imatinib
Mesylate is approved by the FDA for the treatment of chronic myeloid leukemia (CML) and some
types of acute lymphoblastic leukemia (ALL). Its use in combination with CLAG regimen is
considered experimental for the treatment of Acute Myeloid Leukemia / CML blast crisis
The goal of the study is to find out what effects (good and bad) Imatinib Mesylate
(Gleevec)combined with chemotherapy (CLAG regimen) on acute myeloid leukemia.
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Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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