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NCT04571177 Clinical Trial

PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke

Acute Ischemic Stroke Clinical Trial

Official title:
Developing PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke Patients

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT04571177
Other study ID # Version 1.0 28AUG2019
Secondary ID
Status Active, not recruiting
Phase
First received
Last updated
Start date February 1, 2016
Est. completion date December 31, 2025

Study information
Verified date April 2024
Source University of Alberta
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Adult patients who are diagnosed with an acute supratentorial ischemic stroke within 48 hrs of onset will be enrolled into the study. Participants will undergo both a CT Scan and PET scan within 7 days of onset. Participants will have the option to undergo a second PET scan with fluorodeoxyglucose (FDG).

Description:

Patients older than 18 years of age diagnosed with an acute supratentorial ischemic stroke within 48 hrs of symptom onset will be prospectively enrolled. Research imaging will be obtained before 7 days after symptom onset. The patient will receive the standardized treatment protocol at the hospital. Informed consent will be obtained from each patient or a substitute decision maker for each individual imaging study (CTP, Rb PET, and FDG PET). The patient will be given the option of undergoing the CTP imaging with the Rb PET only or both the Rb PET and FDG PET components.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 20
Est. completion date December 31, 2025
Est. primary completion date December 31, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age: >18 yo - Gender: male or female - Acute (within 7 days from symptom onset) Supratentorial Ischemic Stroke Exclusion Criteria: - 1) Planned surgical intervention - 2) Severely abnormal blood glucose level (will be excluded from FDG PET imaging) - 3) Unable to undergo CTP or PET imaging (i.e. claustrophobia) - 4) Pregnancy

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Canada University of Alberta Edmonton Alberta

Sponsors (1)
Lead Sponsor Collaborator
University of Alberta

Country where clinical trial is conducted

Canada, 

Outcome
Type Measure Description Time frame Safety issue
Primary Compare PET brain perfusion imaging to CTP Imaging of CTP images with the Rb PET only or both the Rb PET and FDG PET with CTP imaging components to evaluate blood flow and metabolism mismatches. through study completion, 1 year from start of recruitment
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