Acute Irreversible Pulpitis With Apical Periodontitis Clinical Trial
Official title:
Post Operative Pain and Expression of Substance P, IL8 After the Use of Ketorolac Irrigant Following Single Visit Root Canal Treatment
Endodontic post-treatment pain management is one of the most challenging problems in the clinical practice of endodontics. Although this pain is decreased after root canal treatment, there may be residual symptoms due to inflammation. It has been reported that up to 80% of patients with preoperative pain, will report pain after endodontic treatment, which might range from mild to severe. Management of endodontic pain should involve all steps of treatment including preoperative pain control through accurate diagnosis and reduction of anxiety, intraoperative pain control through effective and profound local anesthetic, operative techniques and that can be achieved through a variety of pharmacologic agents. Many mechanisms have been proposed to explain the reason for postoperative pain including the sensitization of nociceptors by inflammatory mediators. Among these chemical inflammatory mediators are the prostaglandins which is the terminal product of arachidonic acid metabolism, through the cyclooxygenase (COX) pathway. Endodontic treatment can cause the release of inflammatory mediators (e.g. prostaglandins, leukotrienes, bradykinin, platelet- activating factor and substance P) into the surrounding periapical tissues, causing pain fibers to be directly stimulated (by bradykinin for instance) or sensitized (by prostaglandins). In addition, the vascular dilation and increased permeability as a consequence of periradicular inflammation, cause edema and increased interstitial tissue response. Single-visit root canal treatment is common in some endodontic practices. However, one of the main concerns with this approach has been the fear of post- operative pain. Mechanical, chemical and microbiological injuries to the peri- radicular tissues during root canal treatment have been suggested as possible causes of post-operative pain. The role of irrigating solutions used during root canal treatment to help control post-operative pain is unclear. While certain studies have observed a reduction in post-operative pain with particular types and concentrations of irrigating solutions, other studies have reported no difference in post-operative pain with the different irrigating solutions .
When the treatment itself appears to initiate the onset of pain and/or swelling, the result
can be very distressing to both the patient and the operator.
Patients might even consider postoperative pain and flare-up as a benchmark against which the
clinician's skills are measured. Prevalence of postoperative pain or flare-up is, therefore,
one of the influencing factors when making a clinical decision. Better management of
postoperative pain increases the patients' confidence in dentist's skills and gives positive
attitude toward dental profession. The major cause of this pain is thought to be because of
the release of inflammatory mediators that stimulate sensitive nociceptors surrounding the
tooth. The resultant stimulation of both central and peripheral mechanisms is described as
hyperalgesia which is defined as an increase in the perceived degree of a painful stimulus.
One of the many inflammatory mediators, IL-8 has been extensively considered as a potential
marker for irreversible pulpitis. Increased expression of IL-8 is correlated with increased
polymorphonuclear neutrophils (PMNs) within the pulp because IL-8 induces neutrophil
chemotaxis and release of degradation enzymes during degranulation. Substance P was the
initial neuropeptide identified in the dental tissues. The released substance P further
promotes the release of short-lived inflammatory mediators providing a fresh supply of
prostaglandins (iPGE2), leukotriene (iLTB4) and bradykinins. These sustained effects of the
released inflammatory mediators are part of a local positive feedback cycle. Neuronal
responses in the dental pulp due to caries have been shown to alter the anatomical
distribution of nerve fibers, leading to increases in neuropeptide expression and increased
pain sensitivity as a result of peripheral sensitization. Prostaglandin construction in this
inflammatory process is via the cyclooxygenase pathway. Ketorolac tromethamine, a potent
NSAID available in both oral and injectable forms, is over 400 times more potent as a
selective inhibitor of COX-1 over COX-2 than many other drugs. When ketorolac tromethamine
was used as an intracanal medicament in teeth with irreversible pulpitis undergoing root
canal treatment, it contributed to significant post operative pain relief.
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