Acute Heart Failure Clinical Trial
Official title:
Prognostic Value of Serial Biomarker Measurements in Patients With ADHF
Evaluation of serial measurement of novel biomarker for diagnosis, prognosis or therapy monitoring in patients presenting with acute decompensated heart failure.
Background: Heart failure (HF) is a chronic and progressive illness resulting from a variety
of cardiac causes, including ischemic and valvular heart disease, dilatative cardiomyopathy
or hypertension. HF may also develop suddenly, particularly as a complication of acute
myocardial infarction or as an acute exacerbation in patients with previously compensated
chronic HF. Diagnosis and in-hospital management of HF is often demanding and outcome
especially regarding rehospitalizations is impaired. Novel biomarker may be very helpful in
assessment of diagnosis, prognosis, and severity of HF as well as for treatment monitoring.
Design: Prospective, multicenter observational study Setting: University Hospital Basel,
Kantonsspital Aarau, Kantonsspital Luzern, Kantonsspital Wolhusen Patients: Patients with
acute HF not requiring ICU admission
Measurement of serial biomarker (BNP, NT-proBNP, MR-proADM, ST2, hs-cTnI and Copeptin) will
be performed at presentation, at 6 hours (h), 12h, 18h, 24h, at 48h, at day 6 and at
hospital discharge. Follow- up will be performed at 6 Month, 1 year and 2 years.
;
Observational Model: Cohort, Time Perspective: Prospective
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