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Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance — P-Value-AHF  

Acute Heart Failure Clinical Trial

Official title:
Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance (P-Value-AHF): A Multicentre, Randomized, Parallel-group, Open-label Trial

Clinical Trial Summary

The P-VALUE-AHF trial is a multicenter, randomized, open-label, parallel-group trial on the diuretic and decongestive effects of different diuretic escalation strategies in patients with acute heart failure and diuretic resistance. The main aims are - to compare the diuretic efficacy of three therapeutic strategies in patients with acute heart failure and diuretic resistance. - to assess the improvement in clinical congestion and to compare the symptom-relief among the different treatment regimens

Clinical Trial Description

The P-VALUE-AHF trial is a multicenter, randomized, open-label, parallel-group trial on the diuretic and decongestive effects of different diuretic escalation strategies in patients with acute heart failure (AHF) and diuretic resistance (DR). Consenting patients with AHF and DR will be will be randomized towards 3 diuretic regimens. Two to five hours after the initial standard dose Furosemide i.v, - the first group will receive a doubled dose Furosemide (group FF) - the second group will receive a combination of standard dose Furosemide and Metolazone (group FM) - the third group will receive a combination of standard dose Furosemide and Acetazolamide (group FA) Objectives - The primary objective is to compare the diuretic efficacy (measured as natriuresis and urine volume) of three therapeutic strategies in patients with acute heart failure and diuretic resistance. - The secondary objective is to assess the improvement in clinical congestion (EVEREST congestion score) and to compare the symptom-relief (improvement of dyspnoea (VAS)) among the different treatment regimens (FF vs. FM vs. FA). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05986773
Study type Interventional
Source Stadtspital Zürich
Contact Mattia Arrigo, PD, Dr. med.
Phone +41 44 416 30 03
Email mattia.arrigo@stadtspital.ch
Status Recruiting
Phase Phase 4
Start date October 10, 2023
Completion date December 31, 2025
View Details
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