Acute Coronary Syndrome Clinical Trial
— PEACPOfficial title:
Prospective Multicenter Study for Early Evaluation of Acute Chest Pain
In this study, clinical database and blood sample bank of acute chest pain (ACP) will be established at chest pain center of multi-center hospital. To explore new biomarkers and screen clinical indicators with effective risk stratification and prognostic evaluation for ACP through proteomics technology and statistics methods. Risk stratification and short-term and long-term prognostic evaluation models for high-risk ACP will be established using large data analysis.
Status | Recruiting |
Enrollment | 10000 |
Est. completion date | October 31, 2022 |
Est. primary completion date | October 31, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 90 Years |
Eligibility |
Inclusion Criteria: - Patient aged 18-90 years old; - The time from onset of symptoms to emergency room is less than 24 hours. Exclusion Criteria: - Patients complicate with end-stage neoplastic diseases; - Pregnant women; - Patients re-visit during the selection period; - Patients refuse to participate in this study. |
Country | Name | City | State |
---|---|---|---|
China | Chengdu Second People's Hospital | Chengdu | Sichuan |
China | Chengdu Shangjin Nanfu Hospital | Chengdu | Sichuan |
China | People's Hospital of Xindu District | Chengdu | Sichuan |
China | Sichuan Integrative Medicine Hospital | Chengdu | Sichuan |
China | West China Hospital, Sichuan University | Chengdu | Sichuan |
China | Affiliated Hospital of Southwest Medical University | Luzhou | Sichuan |
China | Panzhihua Central Hospital | Panzhihua | Sichuan |
China | Zigong Fourth People's Hospital | Zigong | Sichuan |
China | Affiliated Hospital of Zunyi Medical University | Zunyi | Guizhou |
Lead Sponsor | Collaborator |
---|---|
West China Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Length of stay | Time between patient's visit and discharge | Two weeks | |
Other | Rate of re-admitted participants | Re-admission after discharge within 6 months | Six months | |
Primary | Rate of participants with all-cause death | Patients die of all causes during hospitalization or follow-up | One year | |
Primary | Rate of participants with cardiovascular death | Patients die of cardiac and cerebrovascular diseases during hospitalization or follow-up | One year | |
Primary | Rate of participants with major adverse cardiac events (MACEs) | MACEs include cardiac death, stroke, and recurrent myocardial infarction. | One year | |
Primary | Rate of participants with acute myocardial infarction | Chest pain patients are diagnosed as acute myocardial infarction based on fourth edition of guidelines for myocardial infarction | Twenty-four hours | |
Primary | Rate of participants with acute pulmonary embolism | Chest pain patients are diagnosed as acute pulmonary embolism based on CT of pulmonary angiography. | Twenty-four hours | |
Primary | Rate of participants with acute aortic dissection | Chest pain patients are diagnosed as acute aortic dissection based on CT of aortic angiography. | Twenty-four hours | |
Primary | Rate of participants with acute coronary syndrome | Chest pain patients are diagnosed as acute coronary syndrome based on European Society of Cardiology (ESC) guidelines. | Twenty-four hours | |
Secondary | Rate of participants with ischemia or necrosis of lower limbs | Patients complicate with ischemia or necrosis of lower limbs during hospitalization | Two weeks | |
Secondary | Rate of participants with acute heart failure | Patients complicate with acute heart failure during hospitalization | Two weeks | |
Secondary | Rate of participants with revascularization | Patients receive revascularization for recurrent angina or myocardial infarction during hospitalization | Two weeks | |
Secondary | Rate of participants with consciousness disorder | Patients complicate with consciousness disorder during hospitalization | Two weeks | |
Secondary | Rate of participants with cardiogenic shock | Patients complicate with cardiogenic shock during hospitalization | Two weeks | |
Secondary | Rate of participants with acute kidney injury | Patients complicate with acute kidney injury during hospitalization | Two weeks | |
Secondary | Rate of participants with malignant arrhythmia | Patients complicate with malignant arrhythmia during hospitalization | Two weeks | |
Secondary | Rate of participants with pericardial tamponade | Patients complicate with pericardial tamponade during hospitalization | Two weeks | |
Secondary | Rate of participants with bleeding | Patients complicate with bleeding | One year | |
Secondary | Rate of participants with multiple organ dysfunction syndrome | Patients complicate with multiple organ dysfunction syndrome during hospitalization | Two weeks | |
Secondary | Rate of participants with respiratory failure | Patients complicate with respiratory failure during hospitalization | Two weeks | |
Secondary | Rate of participants with cardiac arrest | The sudden termination of cardiac ejection function, the disappearance of great artery pulsation and heart sound, and severe ischemia and hypoxia of important organs (such as brain) lead to the termination of life. | Two weeks |
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