Evaluating Pancreatic Tumors in Patients With Zollinger-Ellison Syndrome

Zollinger Ellison Syndrome Clinical Trial

Official title:

Evaluation of the Gastrinoma in Patients With Zollinger-Ellison Syndrome

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00001254
• Other study ID #: 900137
• Secondary ID: 90-DK-0137
• Status: Completed
• Start date: October 29, 1991

Study information

• Verified date: September 5, 2023
• Source: National Institutes of Health Clinical Center (CC)
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This protocol concerns the approach to the localization, diagnosis of MEN1 and management of the tumor and the tissue samples in patients with Zollinger-Ellison syndrome. It details the diagnostic imaging tests to be used to localize the tumor, investigations for MEN1 the subsequent management of the tumor and tissue samples for research.

Description:

This protocol concerns the approach to the localization and management of the tumor in patients with Zollinger-Ellison syndrome. It details the diagnostic imaging tests to be used to localize the tumor and the subsequent management of the tumor.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 273
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

• INCLUSION CRITERIA:

New patients will be evaluated initially as described in the protocol entitled, "Diagnostic evaluation of patients with suspected abnormalities of gastric secretion" (89-DK-0005).

Only those patients that are being treated under the protocol entitled, "Medical Therapy of Zollinger-Ellison Syndrome" (protocol # 89-DK-0015) will be entered into this tumor localization and management protocol.

Related Conditions & MeSH terms

• Gastrinoma
• Syndrome
• Zollinger Ellison Syndrome
• Zollinger-Ellison Syndrome

Locations

Country	Name	City	State
United States	National Institutes of Health Clinical Center	Bethesda	Maryland

Sponsors (1)

Lead Sponsor	Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Country where clinical trial is conducted

United States, 

References & Publications (3)

Andersen DK. Current diagnosis and management of Zollinger-Ellison syndrome. Ann Surg. 1989 Dec;210(6):685-703. doi: 10.1097/00000658-198912000-00001. — View Citation

Creutzfeldt W, Arnold R, Creutzfeldt C, Track NS. Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome). Hum Pathol. 1975 Jan;6(1):47-76. doi: 10.1016/s0046-8177(75)80109-2. — View Citation

Wolfe MM, Jensen RT. Zollinger-Ellison syndrome. Current concepts in diagnosis and management. N Engl J Med. 1987 Nov 5;317(19):1200-9. doi: 10.1056/NEJM198711053171907. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To determine an approach to the localization and management of tumor in patients with ZES.	localization of tumor	Yearly

External Links

•   NIH Clinical Center Detailed Web Page