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NCT04247334 Clinical Trial

Inhibitory Control: Effects of Modulation

Young Adults Clinical Trial

Official title:
Brain Circuitry of Inhibitory Control: Effects of Modulation

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04247334
Other study ID # 1352651-9
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date November 14, 2019
Est. completion date April 1, 2024

Study information
Verified date December 2023
Source Butler Hospital
Contact Nicole McLaughlin, PhD
Phone 4014556608
Email nmclaughlin@butler.org
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Inhibitory control is relevant to many clinical disorders, including substance abuse/dependence, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder. This proposal is designed to assess brain networks related to response inhibition in healthy young adults, and use neuromodulation to change these networks and behavioral performance on a response inhibition task. Having an understanding of the brain mechanisms involved in response inhibition may enable us to improve pre-existing treatments for disorders with inhibitory control difficulties.

Recruitment information / eligibility
Status Recruiting
Enrollment 108
Est. completion date April 1, 2024
Est. primary completion date March 1, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 25 Years
Eligibility Inclusion Criteria: 1. Low (<1sd below the mean on the BRIEF-Inhibit) or high (>1sd above the mean on BRIEF-Inhibit scale) 2. English fluency to ensure comprehension of study measures and instructions. Exclusion Criteria: 1. Presence of medical conditions contraindicated for tDCS, including history of any known intracranial pathology, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, current pregnancy or women of childbearing age not using effective contraception, or any other serious medical conditions or health problems that would interfere with participation (e.g., skin condition) 2. Inability to undergo MRI 3. Current substance abuse disorder 4. Currently prescribed psychiatric medications. 5. Active mania or psychosis

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• Transcranial direct current stimulation
20 minutes of 2 milliamp transcranial direct current stimulation

Locations
Country Name City State
United States Butler Hospital Providence Rhode Island

Sponsors (1)
Lead Sponsor Collaborator
Butler Hospital

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary fMRI connectivity at rest Changes in resting state connectivity of the inhibitory control information 2 weeks
Primary fMRI connectivity during a stop signal task Changes in task-based connectivity on the stop signal task 2 weeks
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