Mild Cognitive Impairment Clinical Trial
Official title:
Evaluation of a Navigation Experiment in the Gait Real-Time Analysis Interactive Lab: Gait Analysis by Induced Disorientation in a VR Environment
The aim of the study is to investigate whether the effect of disorientation on physical motion and gait among dementia patients, can be reliably measured in a laboratory environment, by means of a virtual reality (VR) experimental setup.
Challenges in wayfinding and orientation are early symptoms of MCI and dementia. These
deficits decrease mobility which again leads to further cognitive decline. In a field study,
we developed a pattern recognition model of disorientated behaviour based on accelerometric
data. However, it is questionable if phases of disorientation also affect gait parameters.
Furthermore, there is growing evidence that impaired cognitive functioning is associated with
changes in gait performance, e.g. gait variability, measured in dual-task walking conditions.
Increases in heart rate and skin conductance have also been reported during instances of
disorientation.
Hence, We implemented a 3D environment of a familiar city centre in the GRAIL, which combines
a fully instrumented treadmill with a synchronized VR environment. We record gait parameters
through the motion capture system, and accelerometric and physiological data using wearable
sensors (movisens), for comparability with the SiNDeM field study. Young and old healthy
adults will participate in the first phase of the study, while Mild dementia or MCI patients
will participate in the later phases. Phases of disorientation will be induced by changing
the virtual environment.We aim to assess gait, accelerometric and physiological parameters
during instances of disorientation, using the GRAIL (Gait Real-Time Analysis Interactive Lab,
Motekforce Link).
The results will further enable the automatic detection of disorientation based on gait
parameters, physiological and accelerometric data. This is necessary for the development of a
situation-aware assistive system which supports persons with dementia in autonomous outdoor
mobility.
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