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NCT ID: NCT04363450 Recruiting - COVID-19 Clinical Trials

Hydroxychloroquine as Prophylaxis for COVID-19 in Healthcare Workers (HCQPreP)

HCQPreP
Start date: April 27, 2020
Phase: Phase 3
Study type: Interventional

This a double-blind, randomized, placebo-controlled clinical trial to determine if primary prophylaxis with hydroxychloroquine in healthcare workers reduces symptomatic COVID-19 infection. Healthcare workers will be randomized at a 1:1 allocation between intervention and placebo arms and followed for 12 weeks. This study will enroll up to 1,700 participates in Lafayette, Louisiana. The primary outcome will number of symptomatic COVID-19 infections. Secondary endpoints included number of days healthcare workers are absent from work and rate of severe infection.