Argireline in Treatment of Periorbital Wrinkles

Status Completed

Clinical Trial Summary

The purpose of this study is to determine whether La Jolie gel is effective in the treatment of periorbital wrinkles.

Clinical Trial Description

Argireline has mechanism of action that significantly inhibited neurotransmitter release with a potency similar to that of BoNTA. Inhibition of neurotransmitter release was due to the interference of the hexapeptide with the formation and/or stability of SNARE complex. Notably, this peptide did not exhibit in vivo oral toxicity nor primary irritation at high doses. These findings demonstrate that Argireline is a anti-wrinkle peptide that emulates the action of currently used BoNTs.

In vivo study, Topical Argireline 10% is applied on lateral preorbital area twice daily for 30 days. The result demonstrates a significant anti-wrinkle activity by decreased skin wrinkle 30%. These findings demonstrate a significant anti-wrinkle activity for Argireline, in agreement with its in vitro and cellular activities. Topical Argireline represents a bio-safe alternative to BoNTs in anti-wrinkle therapy. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Wrinkles

Clinical Trial Details

NCT number	NCT01381484
Study type	Interventional
Source	Mahidol University
Contact
Status	Completed
Phase	Phase 3
Start date	March 2009
Completion date	September 2009

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01984619` - Prospective Study Evaluating the Treatment of Hyperdynamic Forehead Wrinkles	N/A
Completed	`NCT01713985` - Feasibility Study: Evaluation of Ulthera Versus Thermage for Treating the Face and Neck	N/A
Recruiting	`NCT01586819` - Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A	Phase 3
Completed	`NCT05254210` - Feasibility Study To Collect Safety And Preliminary Efficacy Data For A Radiofrequency Microneedling Device	N/A
Completed	`NCT02604641` - Assessment of the Impact of a Coenzyme Q10 Supplementation on the Skin	N/A
Completed	`NCT01460927` - TriActive+ Radiofrequency (RF) for Non-invasive Treatment of Wrinkles & Rhytides	N/A
Completed	`NCT01519934` - A Retrospective Study to Evaluate the Effectiveness of the Ulthera System	N/A
Completed	`NCT03811756` - The Effect of 12-week Dietary Intake of Syrup Containing CoQ10 and Collagen on Dermis Density and Other Skin Parameters	N/A
Completed	`NCT04988412` - The Effect of 12-week Dietary Intake of Food Supplements Containing Collagen on Dermis Density and Other Skin Parameters	N/A
Completed	`NCT02913547` - Silk'n HST for Wrinkle Reduction - Clinical Study Protocol	N/A
Active, not recruiting	`NCT02019004` - A Pilot Study Testing Onabotulinum Toxin A Versus Incobotulinum Toxin A Injections for Facial Wrinkles	N/A
Completed	`NCT02340078` - A Clinical Study to Evaluate the Efficacy and Safety of YVOIRE Volume Plus Versus YVOIRE Volume in Nasolabial Fold Injection	N/A
Completed	`NCT01283464` - Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles	Phase 2
Completed	`NCT01034956` - Outcomes and Patient Experience After Soft Tissue Dermal Filler Injections	N/A
Completed	`NCT02425943` - Sculptra Aesthetic Post-Approval Study	Phase 4
Recruiting	`NCT05847530` - Pilot Evaluation of the Cynosure Potenza™ System for Treatment of Cosmetic Dermatologic Skin Conditions	N/A
Enrolling by invitation	`NCT01847066` - Epidermal Delivery of Ani-Aging Ingredients	N/A
Completed	`NCT01859611` - TriActive+ Radiofrequency (RF) for Non-Invasive Treatment of Wrinkles and Rhytides	N/A
Completed	`NCT01297634` - Radial Diffusion of the Botulinum Toxin Type A (Botox®): Electromyographic Evaluation of the Frontal Muscle	Phase 4
Completed	`NCT05011461` - The Effect of Topical Almond Oil vs. Topical Retinol on The Appearance of Facial Wrinkles	N/A