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Polytrauma and Resuscitation Impact on Innate Immunity — PRIME  

Wounds and Injuries Clinical Trial

Official title:
Polytrauma and Resuscitation Impact on Innate Immunity

Clinical Trial Summary

Major trauma can lead to a dysregulated response to secondary infection. Severe injuries are accompanied by pro- and antiinflammatory changes that affect both adaptive and innate immunity. In this study we aim to assess cellular immuno-competence early during treatment in an attempt to identify signs of immuno-suppression.

Clinical Trial Description

Polytrauma represents one of the most challenging critical conditions for caretakers worldwide and involves multiple damages of different anatomical regions. Severe traumatic injuries are among the primary causes of death among young people under the age of 45 and half of them are due to uncontrollable bleeding. In the acute injury phase of trauma, severe blood loss is often accompanied by biochemical, cellular and physiological dysfunctions leading to an inflammatory response, infections and in some cases coagulopathy. We aim to identify immuno-suppression by analyzing phagocytic capacity, leukocyte subsets, surface molecule expression and extracellular vesicles in the peripheral blood of severly injured patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06314841
Study type Observational
Source Ludwig Boltzmann Gesellschaft
Contact
Status Terminated
Phase
Start date June 1, 2017
Completion date January 1, 2022
View Details
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