Wounds and Injuries Clinical Trial
Official title:
Long-term Outcome Related Prognostic Factor and Biomarkers of Major Trauma Database Analysis
The investigators were looking for resuscitation management, trauma mechanism, risk factors, and de novo biomarkers related to prognosis and long-term outcome for evaluating trauma patients besides injury severity score (ISS) guiding the traumatologist. The medicare resource could be utilized efficiently along with increasing in the survival and quality of lifer (QoL) in major trauma.
Status | Recruiting |
Enrollment | 500 |
Est. completion date | January 2020 |
Est. primary completion date | January 2020 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 20 Years and older |
Eligibility |
Inclusion criteria: - age ? 20 - willing to join this study and sign the inform consent form by the patients or their contactable families - ISS score ? 16, or meet trauma blue or trauma red criteria - response to primary resuscitation - without uncontrolled or major (>1500mL) bleeding. Exclusion criteria: - active malignancy before the event of major trauma - age <20, pregnancy woman, breast-feeding woman, or mental illness - uncontrolled bleeding with hemoglobin <7g/dL after treatment. |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital | Taipei City |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Event related survival | since major trauma event till trauma related death | 30 days | Yes |
Secondary | Functional status | Besides Rehabilitation Complexity Scale (RCS) and Functional Independence Measure (FIM) for traumatic brain injury patients, Glasgow Outcome Scale - Extended (GOS-E) and European Quality of Life Five Dimensions Questionnaire (EQ-5D) are used in concerning longer-term outcome indicators. There are currently no robust measures of patient experience for use in major trauma. Functional status after the major trauma event could be measured using non-clinical outcomes such as return to work, maintenance of education and societal dependency at post injury 3, 6, and 12 months. | 12 months | No |
Secondary | over all survival | since major trauma event till death | 2 years | Yes |
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