Transfusion-Associated Microchimerism in Previously Injured Individuals

Status Terminated

Clinical Trial Summary

Blood transfusions are frequently necessary in situations in which there is a large amount of blood loss. In some individuals who receive a blood transfusion, white blood cells from the donor's blood may remain in the body for years, a condition known as microchimerism. This study will evaluate the occurrence of microchimerism among the following three groups of individuals who previously received transfusions: 1) individuals with traumatic injuries; 2) individuals with burn injuries; and 3) individuals who underwent elective orthopedic operations.

Clinical Trial Description

Approximately 10% to 15% of injured patients who receive blood transfusions experience a condition known as transfusion-associated microchimerism. This occurs when white blood cells, or leukocytes, from the donor's blood persist in the recipient long after the transfusion occurs. The genetically distinct donor cells can remain in the individual for decades, and may account for as many as 4% of the white blood cells in the recipient's body. This suggests that the donor cells are tolerated by the recipient's immune system. The purpose of this study is to compare the incidence of microchimerism among individuals with three different types of injuries: 1) traumatic injuries; 2) thermal, or burn, injuries; and 3) injuries resulting from elective orthopedic surgical procedures.

In this study, blood samples will be collected from individuals who were treated for traumatic injury, thermal injury, or elective orthopedic surgical procedures at the University of California at Davis Medical Center. Individuals who were treated from 2000 to 2003 and received a blood transfusion, as well as a control group of individuals who did not receive a transfusion, will be approached to enroll in the study. Individuals who agree to participate will have their blood analyzed for evidence of microchimerism. Information on health status, injury characteristics, hospital care, blood transfusion details, and blood donor characteristics will be collected from all participants. ;

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00441779
Study type	Observational
Source	National Heart, Lung, and Blood Institute (NHLBI)
Contact
Status	Terminated
Phase	N/A
Start date	August 2008
Completion date	October 2011

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04554212` - Blood Flow Restriction Training After Patellar INStability	N/A
Suspended	`NCT02932176` - Machine Learning for Handheld Vascular Studies
Recruiting	`NCT04803253` - Study of the Social and Professional Reintegration Improvements Using a Set of Solutions for Upper Limb Amputation	N/A
Completed	`NCT00116337` - Spinal Cord Stimulation to Restore Cough	N/A
Completed	`NCT03463720` - Outcome for Patients With War-Associated Extremity Wound Infection	N/A
Completed	`NCT03113253` - TRANexamic Acid to Reduce Bleeding in BURN Surgery	Phase 4
Not yet recruiting	`NCT05492903` - COMmunity of Practice And Safety Support for Navigating Pain (COMPASS-NP)	N/A
Terminated	`NCT02909231` - One-year Patient Reported Outcomes Following Hospitalization for Trauma	N/A
Completed	`NCT02432456` - Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients	Phase 4
Completed	`NCT02744144` - Wound Bacterial Microbiota and Their Antibiotic Resistance	N/A
Completed	`NCT02266771` - Impact of V.A.C. Veraflo Therapy in Wounds Requiring Debridement Within an Orthopedic Practice	N/A
Completed	`NCT02394821` - Odor Management in Fungating Wounds Comparing Metronidazole and Polihexanide	Phase 3
Not yet recruiting	`NCT01665963` - Efficacy of TopClosure(C)System in Healing Complicated Pacemaker Wounds	N/A
Completed	`NCT00151112` - Comparison of Two Different Procedures for Plexus Anesthesia	N/A
Not yet recruiting	`NCT03872544` - Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
Recruiting	`NCT04596124` - Effectiveness and Tolerability of Fitostimoline Plus Cream and Gauze vs Connettivina Bio Plus Cream and Gauze	N/A
Recruiting	`NCT05800834` - Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds	Phase 2
Enrolling by invitation	`NCT03880188` - Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
Terminated	`NCT04775316` - Prospective, International, Multicenter, Observational Study to Evaluate the Clinical Performance and Safety of a Silicone-coated Transparent Postoperative Dressing
Enrolling by invitation	`NCT03312504` - Implementing a School Prevention Program to Reduce Injuries Through Neuromuscular Training	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Transfusion-Associated Microchimerism in Previously Injured Individuals Who Received a Blood Transfusion

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms