Wounds and Injuries Clinical Trial
Official title:
Prospective Study of the Kinetics and Mechanisms of Transfusion-associated Microchimerism in Injured Patients
Verified date | April 2013 |
Source | Blood Systems Research Institute |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Observational |
Individuals who experience a traumatic injury often have a significant amount of blood loss and may require a blood transfusion. In some individuals who receive a blood transfusion, white blood cells from the donor's blood may remain in the body for years, a condition known as microchimerism. This study will examine the reasons why microchimerism occurs in some blood transfusion recipients and not others.
Status | Completed |
Enrollment | 451 |
Est. completion date | July 2012 |
Est. primary completion date | August 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 12 Years and older |
Eligibility |
Inclusion Criteria: - Hospitalized for a traumatic injury - Received at least one unit of transfused red blood cells Exclusion Criteria: - Currently incarcerated - Inadequate decision-making capacity of the participant and no available surrogate decision-maker - Prior bone marrow or solid organ transplantation |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United States | University of California, Davis, Medical Center | Sacramento | California |
Lead Sponsor | Collaborator |
---|---|
Blood Systems Research Institute | National Heart, Lung, and Blood Institute (NHLBI) |
United States,
Lee TH, Paglieroni T, Utter GH, Chafets D, Gosselin RC, Reed W, Owings JT, Holland PV, Busch MP. High-level long-term white blood cell microchimerism after transfusion of leukoreduced blood components to patients resuscitated after severe traumatic injury. Transfusion. 2005 Aug;45(8):1280-90. — View Citation
Utter GH, Owings JT, Lee TH, Paglieroni TG, Reed WF, Gosselin RC, Holland PV, Busch MP. Blood transfusion is associated with donor leukocyte microchimerism in trauma patients. J Trauma. 2004 Oct;57(4):702-7; discussion 707-8. — View Citation
Utter GH, Owings JT, Lee TH, Paglieroni TG, Reed WF, Gosselin RC, Holland PV, Busch MP. Microchimerism in transfused trauma patients is associated with diminished donor-specific lymphocyte response. J Trauma. 2005 May;58(5):925-31; discussion 931-2. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Prevalence and magnitude of transfusion-associated microchimerism | 1, 2 and 4 weeks, 3 and 6 months | No |
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