Adipose Tissue Extract and Platelet-rich Plasma Use for Wound Healing

Wound Healing Disturbance of Clinical Trial

Official title: The Effect of Adipose Tissue Extract and Platelet-rich Plasma on Split-thickness Donor Site Wound Healing. A Comparative Study

Status Completed

Clinical Trial Summary

Adipose Tissue Extract (ATE) has been found to be an autologous source of growth factors with proven in vitro angiogenic and adipogenic properties.It is obtained by a simple lipoaspirate procedure. We sought to compare the effect of ATE with another known source, platelet-rich plasma to compare the wound healing characteristics on skin graft donor sites.

Clinical Trial Description

The investigators enrolled 24 participants with an indication for skin graft. Two or more split-thickness grafts are harvested per patient, one serving as control and the other as experimental. The experimental sites were covered with either autologous PRP gel or ATE prepared in the OR, which was selected in an unblinded manner due to surgical theater convenience. However, donor sites were randomized through a computer generator. Covered with a semiocclusive film, wounds were separated and followed up on days 3,5,7,10,14 for wound healing and 30 and 60 for scar evaluation. Digital photography and specto-photocutometry was employed to know the hemoglobin and melanin content of the wounds, and custom-made software was used to calculate the percentage of wound re-epithelialization. ;

Related Conditions & MeSH terms

• Wound Healing Disturbance of
• Wounds and Injuries

• NCT number: NCT02799290
• Study type: Interventional
• Source: Tampere University
• Status: Completed
• Phase: Phase 2
• Start date: June 2015
• Completion date: May 2016