Wound Heal Clinical Trial
Official title:
Assessment of Bone Healing After MTA and PRF Application in Periapical Lesions By Using CBCT
A total of 40 periapical lesions from the 33 patient undergoing apical surgery were randomly
selected from December 2016-November 2017. Patients were informed about the surgical
procedure and signed a consent form. Groups were divided in to 4; as control, MTA (mineral
trioxide aggregate), PRF (platelet rich fibrin) and MTA+PRF groups. Apical resection was
performed in all groups. No other interventions were made to the control group.
Routine radiographs were taken in the 1st. 3th and 6th months. In the (approximately) 12th
month of the procedures computerized tomography scans were taken. Primary healing of the
periapical tissues were evaluated and the outcomes were measured. Patients have still been
under control for the long term outcomes of the study.
44 apically infected periapical lesions were decided to enroll to the study from December
2016-November 2017. However; a total of 40 periapical lesions undergoing apical surgery were
recruited for the planned clinical trial in the end. The study was conducted under randomized
controlled protocol. Patients were informed about the surgical procedures and signed a
consent form. The anticipated outcomes, possible risks and benefits of the study as well as
the alternative treatment options were explained to the patients.
Groups were designed to have 10 patients in each and randomly divided into four as; control,
MTA, PRF and MTA+PRF. Apical resection was performed in all groups. No other interventions
were made to the control group.
Routine radiographs were taken in the 1st. 3th and 6th months. In the 12th month of the
procedures computerized tomography (CT) scans were taken. Primary healing of the periapical
tissues were evaluated according to the volumes and the densities of the lesions. Outcomes
were measured. Comparison between the initial and the last 3D CT scan volumes were made by
medical image processing software (MIMICS, Belgium). Patients have still been under control
for the long term outcomes of the study.
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