Topical Insulin for Postoperative Wound Healing

Status Active, not recruiting

Clinical Trial Summary

This study aimed to investigate the potential effect of applying topical insulin therapy on the management and healing of postoperative wounds in patients known with type 2 diabetes mellitus (T2DM) and in a parallel group without diabetes. Investigators also studied the effect of topical insulin therapy on the expression of e-cadherin and Ki67, as markers for cellular proliferation and wound repair. The levels of IL-6 and the H2O2-induced DNA damage product, 8-hydroxy-2'-deoxyguanosine (8-OHdG), were assessed as markers for inflammation and oxidative stress. Finally, histomorphological assessment of skin biopsies was also carried out.

Clinical Trial Description

The study participants will be recruited from general surgery department ,all patients with elective surgical procedure who will be admitted at the department for at least one week as it is the minimal duration of postoperative wound healing and the study will be conducted according to the regulations of ethical committee of clinical studies in the Faculty of Medicine, Cairo University ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06400082
Study type	Interventional
Source	Cairo University
Contact
Status	Active, not recruiting
Phase	N/A
Start date	April 16, 2023
Completion date	July 10, 2024

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