Clinical Trials Logo

Clinical Trial Summary

In France, In recent years, there has been a steady increase in reports of abuse and dependence on tramadol. Over 50% of tramadol withdrawal syndromes involve taking tramadol in therapeutic doses, sometimes for short periods of less than a week. Physical dependence can develop when a therapeutic maintenance dose is prescribed for the treatment of mild to moderate pain. Due to its mixed mechanism of action, tramadol withdrawal syndromes are not only characterized by classic signs of opioid withdrawal (muscle pain, mydriasis, sweating, nausea and vomiting, tearing, rhinorrhea, yawning, fever, insomnia, etc.). The properties of this substance on serotonin explain the effects which are added to the morphine-mimetic withdrawal of tramadol. Analysis of spontaneous reports shows "psychological and psychic" signs of withdrawal. Currently, there is no validated protocol for the management of tramadol withdrawal. The main objective is to assess the different options for managing tramadol withdrawal: opioid maintenance therapy and symptomatic treatments, in relation to the addictive and psychiatric co-morbidities in patients. The study also provides insight into the different types of withdrawal syndromes experienced by patients in order to raise awareness among doctors when prescribing tramadol.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT04550754
Study type Observational
Source University Hospital, Montpellier
Status Completed
Start date September 17, 2020
Completion date June 1, 2021

See also
  Status Clinical Trial Phase
Recruiting NCT02249026 - Sublingual Buprenorphine Treatment for Neonatal Abstinence Syndrome - Pilot Study Phase 1/Phase 2
Recruiting NCT04610476 - Impact of Tapering Immunosuppressants on Maintaining Minimal Disease Activity in Adult Subjects With Psoriatic Arthritis Phase 3
Recruiting NCT06066996 - Evaluation of the Electronic Cigarette Withdrawal Syndrome Early Phase 1
Completed NCT01431326 - Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Completed NCT04105712 - The Biobehavioral Impact of Diet Quality on Affect and Craving N/A
Completed NCT03376308 - Evaluation of the Effect of Venous Diameter Measurement by Ultrasonography on Pain and Withdrawal Response N/A
Recruiting NCT05964738 - Effect of Diuretics Withdrawal in Chronic Heart Failure With Reduced Ejection Fraction Phase 2
Completed NCT03973801 - Feasibility of Auricular Acupressure as an Adjunct Treatment for Neonatal Abstinence Syndrome (NAS) N/A
Completed NCT03462797 - Opioid Physiology Project
Completed NCT01818895 - Terminal Weaning of Mechanical Ventilation or Extubation in Anticipation of Death in the Intensive Care Unit N/A