Wiskott-Aldrich Syndrome Clinical Trial
Official title:
Post-transplant Cyclophosphamide for HLA-haploidentical Transplantation in Wiskott-Aldrich Syndrome
Verified date | June 2017 |
Source | Capital Research Institute of Pediatrics |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
A protocol named as "CIP-2015" for patients with Wiskott-Aldrich Syndrome may reduce the
rate of GvHD.
The details of the protocal followed with:
1. Conditioning regimen Busulfan 16 mg/kg in total, Fludarabine 160 mg/m2 in total.
2. GvHD Prophylaxis:
Rabbit antihuman thymocyte globulin 7.5 mg/kg post-transplant cyclophosphamide (CY) (50
mg/kg.d on days +3 and +4) Cyclosporine or tacrolimus, mycophenolate mofetil, on days +5
Status | Enrolling by invitation |
Enrollment | 5 |
Est. completion date | July 10, 2020 |
Est. primary completion date | March 10, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 5 Months to 10 Years |
Eligibility |
Inclusion Criteria: -Patients diagnosed with Wiskott-Aldrich Syndrome with indication of Hematopoietic stem cell transplantation Exclusion Criteria: - without indication of Hematopoietic stem cell transplantation |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Capital Research Institute of Pediatrics |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rate of aGvHD | after post transplant cyclophospamide | 3month |
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