Clemastine Treatment in Individuals With Williams Syndrome

Status Recruiting

Clinical Trial Summary

This study explores the neurobiological etiology of Williams syndrome and potential therapeutic targets for associated social, motor, and cognitive abnormalities. The main translational objective will be to test the effectiveness of Clemasntine on neurocognitive and other associated abnormalities in individuals with Williams syndrome.

Clinical Trial Description

The overarching aim of the research proposed is to examine the safty of Clemastine use for individuals with Williams syndrome. Further, we wish to examine the relationship between Clemastine treatment and cognitive, motor and behavioral deficits in individuals with Williams syndrome. This study is an open-label study with a blinded randomize withdrawal. Each participant will go through a baseline evaluation (see study outcomes) and will be treated with the FDA approved drug Clemastine, in an age dependent dose (dosage table below). After a substantial improvement will be noticed, the participants will be divided into 2 groups, in a randomized, double-blind, placebo-control study design. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06087757
Study type	Interventional
Source	Sheba Medical Center
Contact
Status	Recruiting
Phase	Phase 3
Start date	April 1, 2024
Completion date	December 2025

View Details

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