White Spot Lesion Clinical Trial
Official title:
Remineralization Potential of Curodont Repair Flouride Plus Versus CPP-ACP in Management of White Spot Lesions: Randomized Clinical Trial
The goal of modern dentistry is to manage non-cavitated caries lesions non- invasively
through re-mineralization process to prevent the disease progression and improve aesthetics,
strength, and function. Re-mineralization is defined as the process that supplies calcium,
phosphate and flouride ions from an external source to the tooth to convert ion deposition
into crystal voids in demineralized enamel. White spot lesions should be managed using a
multifactorial approach. The most important strategy is to prevent demineralization and
biofilm formationand use of methodologies for remineralization of lesions .
Self-assembling peptide (P11-4) has shown great potential for natural repair of early caries
lesions through emerging biomimetic re-mineralization properties. (Takahashi Fet al in 2015)
This peptide forms a 3D matrix within demineralized carious lesions areas, which enables novo
hydroxyapatite crystal formation facilitating the so-called guided enamel regeneration of the
lost enamel structure. The peptide has shown encouraging results as a scaffold for enamel
regeneration
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