White Spot Lesion Clinical Trial
Official title:
Remineralization Potential of Curodont Repair Flouride Plus Versus CPP-ACP in Management of White Spot Lesions: Randomized Clinical Trial
The goal of modern dentistry is to manage non-cavitated caries lesions non- invasively
through re-mineralization process to prevent the disease progression and improve aesthetics,
strength, and function. Re-mineralization is defined as the process that supplies calcium,
phosphate and flouride ions from an external source to the tooth to convert ion deposition
into crystal voids in demineralized enamel. White spot lesions should be managed using a
multifactorial approach. The most important strategy is to prevent demineralization and
biofilm formationand use of methodologies for remineralization of lesions .
Self-assembling peptide (P11-4) has shown great potential for natural repair of early caries
lesions through emerging biomimetic re-mineralization properties. (Takahashi Fet al in 2015)
This peptide forms a 3D matrix within demineralized carious lesions areas, which enables novo
hydroxyapatite crystal formation facilitating the so-called guided enamel regeneration of the
lost enamel structure. The peptide has shown encouraging results as a scaffold for enamel
regeneration
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05710874 -
A Prospective, Randomized, Clinical Study on the Effects of CPP-ACP-paste, Fluoride and a Combination on the Evolution of White Spot Lesions in Orthodontic Patients After Debonding.
|
N/A | |
| Completed |
NCT04107012 -
Evaluation of Enamel Demineralization During Clear Aligner Orthodontic Treatment
|
N/A | |
| Active, not recruiting |
NCT04342858 -
Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment
|
Phase 2 | |
| Recruiting |
NCT05989750 -
Air-polishing With Erythritol During Orthodontic Tretament
|
N/A | |
| Completed |
NCT06200129 -
İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin
|
N/A | |
| Not yet recruiting |
NCT03976583 -
Remineralization Potential of Pearl Powder Compared to CPP-ACP on Enamel White Spot Lesions
|
Phase 2 | |
| Not yet recruiting |
NCT06051981 -
White Spot Lesions Treatment in Orthodontic
|
Phase 4 | |
| Not yet recruiting |
NCT04422860 -
Remineralization Efficacy of Gum Arabic Varnish.
|
Phase 2/Phase 3 | |
| Completed |
NCT04560478 -
Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients
|
N/A | |
| Completed |
NCT02027922 -
Clinical Effectiveness of Various Professionally Applied Fluoride Prophylaxes in Groups at High Risk
|
N/A | |
| Completed |
NCT04908293 -
Home Remineralization of White Spot Lesions With Two Different Toothpastes.
|
N/A | |
| Not yet recruiting |
NCT05868603 -
Effect of Different Remineralization Gels
|
N/A | |
| Not yet recruiting |
NCT06331442 -
The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients
|
N/A | |
| Not yet recruiting |
NCT05306691 -
Remineralizing Efficacy of Giomer Varnish vs. Fluoride Varnish in Management of White Spot Lesions in Adult Patients
|
Early Phase 1 | |
| Active, not recruiting |
NCT06166849 -
Clinical Evaluation of an Experimental Remineralization Product
|
N/A | |
| Completed |
NCT05775250 -
Evaluation of Two Varnishes on the Improvement of White Spot Lesions in Children
|
N/A | |
| Completed |
NCT03114475 -
Effect of CO2 Laser on Enamel White Spot Lesion Formation Around Orthodontic Brackets
|
N/A | |
| Active, not recruiting |
NCT06403371 -
The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients
|
N/A | |
| Completed |
NCT05771077 -
Effect of Poly Amido Amine Dendrimer, Nano-hydroxyapatite
|
Phase 1 | |
| Completed |
NCT05721586 -
Self-assembling Peptide With Sodium Fluoride in Treating White Spot Lesionss in Primary Teeth
|
N/A |