White Matter Pathology in Parkinson's Disease (PD)

White Matter Lesions Clinical Trial

Official title: The Role of White Matter Pathology in the Development of the Postural Instability and Gait Disturbance (PIGD) Type of Parkinson's Disease (PD)

Status Not yet recruiting

Clinical Trial Summary

The relationship between WM lesions (WM) and Postural Instability Gait Disorders (PIGD-PD)in Parkinson's disease patients is largely unknown. We hypothesize that sub-clinical WM pathology may be a major contributing factor to PIGD-PD. We will compare two groups of patients with Parkinson's disease (PD): those with PIGD and patients with dominant tremor (n=120)to assess the role of brain WM changes.

Clinical Trial Description

To compare brain WM burden using MRI in PD patients with and without PIGD. Diffusion tensor imaging (DTI) analysis techniques will be applied.We will quantify PIGD-related symptoms including cognitive function, balance and gait and their associations with MRI findings. ;

Study Design

Observational Model: Case Control

Related Conditions & MeSH terms

• Parkinson Disease
• Postural Instability Gait Disorders
• White Matter Lesions

• NCT number: NCT01039831
• Study type: Observational
• Source: Tel-Aviv Sourasky Medical Center
• Contact: Nir Giladi, MD
• Phone: +972-3-6974790
• Email: ngiladi@tasmc.healht.gov.il
• Status: Not yet recruiting
• Phase: N/A
• Start date: January 2010
• Completion date: January 2012