White Matter Injury Clinical Trial
Official title:
A Cohort Study on the Etiology and Pathological Types of Brain White Matter Injury in Late Preterm Infants
At 34 weeks, the brain weight of preterm infants is only 65% that of term infants, and the cortex volume is 53% that of term infants. Damage at this stage of development will also change the trajectory of specific processes in the development of neurons and glial cells, resulting in neurological dysfunction in survivors.The incidence of cerebral palsy in late preterm infants is three times higher than in term infants, and about 25% lag behind term infants in learning, language and other neurodevelopment. At 34-37 weeks of gestation, oligodendrocytes are still late oligodendrocyte precursors and vascular development of the white matter area is immature, making the brain more prone to white matter injury (WMI).
1.1Patients Late preterm infants who were hospitalized in Shengjing Hospital from 1st January
2009 to 31st December 2022.
Risk factors prompting MRI evaluation included: (1) premature rupture of fetal membrane,
intrauterine distress or placental abruption before delivery; (2) asphyxia, resuscitation and
rescue history, circulatory dysfunction and infection during or after delivery; and (3) early
convulsions.
1.2 Assessment of brain injury MRI scans were analyzed by a radiologist and a newborn
pediatrician who were unfamiliar with the clinical history. WMI diagnosis was carried out as
described by reference, with some improvements.
1.3 Collection of clinical data Data, including delivery by cesarean section, gestational
hypertension, diabetes mellitus, premature rupture of membranes and placental abruption, were
collected for the mothers. Gestational age, weight, gender, whether small for gestational
age, Apgar score, resuscitation history, circulatory disorders, early-onset sepsis,
convulsions, and MRI data were collected for the newborns.
History of resuscitation and rescue refers to positive pressure ventilation, tracheal
intubation, chest compression or epinephrine application during labor; circulatory disorders
include at least two of the following indicators: prolonged capillary filling time,
hypotension, oliguria, increased heart rate and increased liver.
1.4 Instrumentation MRI of the head was performed using an Intera Achieva 3.0T MRI system
(Philips, Best, Netherlands). All infants were scanned by conventional MRI and
diffusion-weighted imaging (DWI). Because of the retrospective study design, there are
differences in imaging schemes, sequences and parameters measured.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01936246 -
Protein Supplementation in Infants With Brain Injury
|
N/A |