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Shifting Away From Pain: Neurocognitive Approach to Explain and Predict Recovery Following Whiplash Injury

Whiplash Injuries Clinical Trial

Official title:
Shifting Away From Pain: Neurocognitive Approach to Explain and Predict Recovery Following Whiplash Injury

Clinical Trial Summary

Around half of the patients with neck pain after trauma (whiplash) will develop chronic pain. Understanding the transition from acute to chronic pain after whiplash is a priority since will help to identify those which patients are likely to fully recover and who do not. In the last years, there have been a call for an investigation of new biomarkers; particularly in brain structure and function. Alterations in the structure of the brain (gray matter, white matter and cortical thickness) as well as the brain function have been found in people with chronic WAD; which are also correlated with pain, disability and symptoms of central sensitization such as hyperalgesia. Previous research has found structural and functional brain differences between people who develop chronic low back pain compared to those who recovered; but research in this vein is still lacking in people with whiplash. Consequently, this study aims to examine the neural correlates of recovery following whiplash injury.

Clinical Trial Description

This study aims to investigate whether or not there are differences in brain structure and function between people who recover after whiplash and those who do not. Thus, patients with acute neck pain after whiplash will be recruited. Also, a pain-free age- and sex-matched control group will be recruited for comparison. A longitudinal prospective study will be conducted with two follow-up measurements (3 and 6 months). All measurements will take place at University Hospital of Ghent (UZ Gent), Ghent (Belgium). MRI measures will be taken at baseline (<4 weeks after the accident) and 6-months follow-up. The 3-months follow-up will only consist of the assessment of the online questionnaires; so, patients will not be required to come to UZ Gent. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05161767
Study type Observational
Source University Ghent
Contact
Status Terminated
Phase
Start date January 6, 2020
Completion date January 10, 2024
View Details
See also
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