Prevention of West Syndrome With Low-dose Adrenocorticotropin Hormone (ACTH) — PREVENT-WS  

West Syndrome Clinical Trial

Official title: Early Treatment of Infants at High Risk of Developing West Syndrome With Low-dose Adrenocorticotropin Hormone (ACTH)

Status Active, not recruiting

Clinical Trial Summary

West syndrome (WS) is a specific type of epilepsy (or seizure disorder) that has three features: infantile spasms (type of seizure), loss of milestones, and a specific pattern on electroencephalogram (EEG or brain wave test) called hypsarhythmia. The purpose of this study is to detect pre-hypsarhythmia in infants at high-risk for WS and determine whether treatment with ACTH will prevent WS.

Clinical Trial Description

Hypothesis: Preemptive ACTH will halt the evolution of hypsarhythmia and improve the EEG patterns in infants with pre-hypsarhythmic EEG.

Aim. To determine whether a low dose ACTH improves EEG, we will repeat EEG one month after a 2 week course of daily ACTH. ;

Related Conditions & MeSH terms

• Spasms, Infantile
• Syndrome
• West Syndrome

• NCT number: NCT01367964
• Study type: Interventional
• Source: Ann & Robert H Lurie Children's Hospital of Chicago
• Status: Active, not recruiting
• Phase: N/A
• Start date: July 2011
• Completion date: December 2018