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Does Dapagliflozin Provide Additional Health Benefits To Dietary Counseling For Weight Loss?

Weight Loss Clinical Trial

Official title:
Does Dapagliflozin Provide Additional Health Benefits To Dietary Counseling For Weight Loss?

Clinical Trial Summary

Dapagliflozin is a medicine to treat diabetes. Its mechanism of action is via sodium-glucose co-transporter 2 (SGLT2) inhibition. In adults with diabetes, use of sodium-glucose co-transporter 2 inhibitors is associated with moderate weight (fat) loss, in addition to other health benefits, including decreased blood pressure, decreased inflammation, and decreased oxidative stress. It is unclear as to whether these health benefits are due to SGLT2 inhibition per se, or as a secondary effect of weight loss. We wish to compare the health benefits of dietary counseling for weight loss with and without concomitant use of an SGLT2 inhibitor.

Clinical Trial Description

This is a randomized, prospective, placebo-controlled, double blind, repeated measures study. 50 overweight/obese adults (body mas index > 27.5 kg/m2) will be recruited for participation and randomly assigned to one of two 12 week treatments: (1) daily oral administration of Dapagliflozin with dietary counseling to promote weight loss; or, (2) daily oral administration of a placebo with dietary counseling to promote weight loss. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03180489
Study type Interventional
Source Colorado State University
Contact
Status Completed
Phase Phase 2
Start date May 3, 2017
Completion date December 21, 2018
View Details
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