Resistant Starch and Whey Protein on Energy Metabolism

Weight Loss Clinical Trial

Official title:

Combined Effects of Dietary Supplementation With Dietary Resistant Starch (RS) and Whey Protein on Resting Energy Expenditure and Blood Sugar and Insulin Responses in Lean and Obese Men and Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02418429
• Other study ID #: 1307-348
• Status: Completed
• Phase: N/A
• Start date: August 2013
• Est. completion date: August 2018

Study information

• Verified date: September 2018
• Source: Skidmore College
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Recent evidence shows that dietary supplementation with resistant starch (RS) increases fat catabolism and resting energy expenditure and decreases plasma insulin and glucose responses as well as the gut-derived hormone, glucose-dependent insulinotropic polypeptide (GIP). Consumption of whey protein has also been shown to increase energy expenditure and favorably affect gut hormones. Thus, investigators tested consumption of both RS and whey protein on energy expenditure and gut hormones in lean and obese women and men.

Description:

Consumed separately, resistant starch (RS) and whey protein (WP) favorably affect energy metabolism and gut hormones, as well as suppress feelings of hunger. These findings are important because release of certain gut hormones (i.e., GIP) is associated with a lower resting energy expenditure (REE) in healthy humans. Interestingly, a recent study showed that ingestion of RS reduces postprandial GIP and increases postprandial REE and fat utilization in healthy men and therefore may be an effective strategy in weight management. Thus, there is a need to replicate these findings in a healthy cohort of lean and obese women and men.

The purpose of this study was to examine the effects of RS on the number of calories burned after eating a meal, as well as specific hormones that are released from the stomach and intestines following meal ingestion in healthy lean and obese women and men. Investigators used a single ingestion of a meal supplemented with or without the resistant starch and whey protein.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: August 2018
• Est. primary completion date: December 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years to 65 Years

Eligibility

Inclusion Criteria:

• overweight or lean but otherwise healthy

Exclusion Criteria:

• Participants will be excluded if they smoke; have experienced excessive weight loss/gain of > ±2kg in the previous 2 months; are currently taking medications for cardiovascular or metabolic disease.

Related Conditions & MeSH terms

• Weight Loss

Intervention

Other:
• waxy maize starch
pancake test meal with waxy maize starch only
• waxy maize starch and Whey Protein
pancake test meal with waxy maize starch and whey protein
• Resistant Starch
pancake test meal with resistant starch only
• resistant starch and whey protein
pancake test meal with resistant starch and whey protein

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Skidmore College

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in fat oxidation from Baseline to 180 Minutes Postprandial	indirect calorimetry of fuel utilization	time 0, 60, 120, 180 minutes
Secondary	Change in gut hormones from Baseline to 180 Minutes Postprandial	gastro-entero-pancreatic hormones	time 0, 60, 120, 180 minutes
Secondary	Change in self-reported feelings of hunger, fullness, satiation from Baseline to 180 Minutes Postprandial	visual analog scale of hunger, fullness and satiation	time 0, 60, 120, 180 minutes