Effect of Exercise-Induced Weight Loss on Energy Metabolism

Weight Loss Clinical Trial

Official title:

E-MECHANIC Ancillary Study: Effect of Exercise-Induced Weight Loss on Energy Metabolism

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01775163
• Other study ID #: PBRC 10008-A
• Status: Completed
• Start date: December 2010
• Est. completion date: February 2015

Study information

• Verified date: August 2021
• Source: Pennington Biomedical Research Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The E-MECHANIC Ancillary Study will measure changes in 24-hour energy expenditure and spontaneous physical activity in a subset of 60 obese individuals enrolled in the main study. We aim to determine if changes in energy metabolism might explain why people don't lose the expected amount of weight in an exercise program.

Description:

This is an ancillary study to E-Mechanic, which is an National Institutes of Health study in 198 individuals with the objective to understand why certain people fail to lose weight in exercise programs. In E-Mechanic changes in body weight, body composition, energy intake and energy expenditure are measured before and after 3 different exercise programs of 24 weeks in duration. The 3 exercise programs being compared are self-directed exercise, low dose exercise and high dose exercise. The goal of this ancillary study is to undertake comprehensive assessments of energy metabolism in a metabolic chamber in a group of 60 obese individuals enrolled in the main study. We will compare differences in the changes in 24h energy expenditure and spontaneous physical activity between the 3 exercise programs. We will also test if changes in energy metabolism might explain why people don't lose the expected amount of weight after 24 weeks of exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 54
• Est. completion date: February 2015
• Est. primary completion date: February 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Individuals enrolled in the E-MECHANIC main study (NCT#01264406) with a body mass index (BMI) greater than or equal to 30 kg/m2.

Exclusion Criteria:

• Not enrolled in the E-MECHANIC main study (NCT#01264406).

• Have a body mass index (BMI) less than 30 kg/m2.

Related Conditions & MeSH terms

• Body Weight
• Metabolism
• Weight Loss

Locations

Country	Name	City	State
United States	Pennington Biomedical Research Center	Baton Rouge	Louisiana

Sponsors (1)

Lead Sponsor	Collaborator
Pennington Biomedical Research Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Sleeping energy expenditure	Sleeping energy expenditure will be measured in a room calorimeter before and after a 24 week exercise program	24 weeks
Other	Spontaneous physical activity	Spontaneous physical activity will be measured in a room calorimeter before and after a 24 week exercise program	24 weeks
Primary	Change in 24h energy expenditure	24h energy expenditure will be measured in a room calorimeter before and after a 24 week exercise program	24 weeks
Secondary	Metabolic adaptation in 24h energy expenditure	The difference between the actual change in 24 energy expenditure and the energy expenditure estimated on the basis of body size will be compared between: 1) exercise groups and 2) between individuals who lost the expected amount of weight and individuals who did not lose the expected amount of weight during the exercise program	24 weeks