Weaning Failure Clinical Trial
Official title:
Application of Lung Ultrasound for Predicting Outcome of Weaning From Mechanical Ventilation
Lung aeration loss can be measured via lung ultrasound, it is a non-invasive, bed side procedure, which can be performed rapidly and facilitates a dynamic assessment of lung aeration. Aim of the work: is to determine the role of lung ultrasound score as one of the predictors of successful weaning from mechanical ventilation in ICU patients.
Patients should be assessed daily for their readiness to be weaned from mechanical
ventilation, sedation must be withdrawn and all patients will be put on a spontaneous
breathing trial (SBT), via T-piece, for 60 -120 minutes period, when they fulfil the weaning
criteria. Patients who succeed to tolerate SBT will be extubated and monitored for signs of
respiratory distress.
Clinical assessment during and after SBT:
- The ability of maintaining a respiration rate of less than 35/min, and keeping oxygen
saturation more than 90%.
- Arterial blood gases (ABGs) will be done 30-60 minutes after SBT and after extubation.
- To detect signs of respiratory distress: diaphoresis, tachypnea (RR> 35/min), increase
activity of accessory muscles of respiration, tachycardia (heart rate > 140 beats per
minute), systolic blood pressure > 180 mmHg or <90 mmHg, appearance of new arrhythmia,
or alteration in mental status (drowsiness or anxiety). ABGs: PaO2 ≤ 60 mmHg or oxygen
saturation < 90% on FiO2 ≥ 0.4, PaCO2 > 50 mmHg, or an increase in by ≥ 8 mmHg, pH <
7.32 or a decrease in pH by ≥ 0.07 pH units.
Clinical assessment will be done by an intensivist who will be blinded to the LUS score
results.
Lung ultrasound (LUS): will be performed while patients in supine position, with a curved
probe on B- mode, using longitudinal view, to assess the amount of lung aeration. Each lung
will be divided into anterior, lateral and posterior regions, each part will be divided to
upper and lower zone, with total of 12 zones to undergo examination. Examination will be done
by an expert physician in US.
Lung US score [9]: The 12 scanned regions will be summed to calculate the LUS score, which
ranged from 0 and 36. In each zone, the worst ultrasound form will considered to be
descriptive of the entire region.
- Score of 0: Normal aeration is signified by the presence of horizontal A lines, lung
sliding, or less than 3 vertical B lines.
- Score of 1: moderate loss of aeration is characterized by multiple regularly or
irregularly spaced B lines that originated from the pleural line.
- Score of 2: Severe loss of aeration is manifested by multiple coalescent B lines in
several intercostal spaces of the specific zone. Detected in alveolar-interstitial
syndrome.[
- Score of 3: Complete loss of aeration, as detected in lung consolidation or atelectasis,
is characterized by tissue echogenicity, which is similar to liver or splenic tissues.
The score will be performed before starting and at the end of SBT (before extubation), or on
developing respiratory distress during SBT.
Patients will be classified according to the possible outcome:
Successful weaning: patients who will not need re-intubation within 48 hours after
extubation.
SBT failure: which will be diagnosed by the appearance of signs of respiratory distress
during SBT and patients will be connected again to the ventilator. Extubation failure: will
be defined as patients who developed signs of respiratory distress after extubation within
48hs and need reintubation or non-invasive ventilatory support.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05539599 -
Comprehensive Ultrasound Evaluation as a Predictor of Weaning
|
||
Completed |
NCT02845076 -
Weaning From Noninvasive Ventilation
|
N/A | |
Completed |
NCT01915563 -
Rest After Spontaneous Breathing Trial for Prevention of Post-extubation Failure
|
N/A | |
Recruiting |
NCT01721434 -
Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients
|
Phase 2/Phase 3 | |
Completed |
NCT01928277 -
Weaning From Mechanical Ventilation: Spontaneous Breathing Trial and the Assessment of Work of Breathing
|
N/A | |
Recruiting |
NCT05632822 -
Value of Diaphragm Function Predicting Weaning From Mechanical Ventilation
|
||
Completed |
NCT06332768 -
NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients
|
N/A | |
Completed |
NCT03240263 -
Inspiratory Muscle Training in Difficult to Wean Patients
|
N/A | |
Completed |
NCT01867853 -
Volume Responsiveness Before SBT Predicts the Outcome of Mechanical Ventilation Weaning in Critically Ill Patients
|
N/A | |
Recruiting |
NCT06040138 -
Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure
|
||
Completed |
NCT06224010 -
Respiratory Drive and Inspiratory Effort in COVID-19 Associated ARDS
|
||
Completed |
NCT03129217 -
The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated Patients
|
||
Completed |
NCT05550220 -
A Modified Cuff Leak Test and Reintubation in Mechanically Ventilated Patients
|
N/A | |
Not yet recruiting |
NCT05431036 -
Evaluation of a Combined Model in Predicting Weaning Outcome in Critically Ill Patients.
|
||
Recruiting |
NCT05906888 -
Weaning With Tracheostomy - an Observational Study on Patient-centered Outcomes
|
||
Recruiting |
NCT05944588 -
Predictive Value of Chest Ultrasound Observation on Extubation Failure
|
||
Not yet recruiting |
NCT05802745 -
P0.1 and Extubation Failure in Critically Ill Patients
|
||
Recruiting |
NCT03894189 -
The Effect of Doxapram Versus Theophylline on Diaphragmatic Function
|
N/A | |
Completed |
NCT01877850 -
Utility of a Weaning Protocol in ICU
|
N/A | |
Completed |
NCT03580720 -
Electromyography for Diaphragm Effort
|
N/A |