Weaning Failure Clinical Trial
Official title:
Weaning From Mechanical Ventilation: Spontaneous Breathing Trial and the Assessment of Work of Breathing
The main objective of the study is to examine the extent of agreement between patient and health care provider assessments of work of breathing and the association of agreement with demographic- and disease-related factors.
Mechanical ventilation is among the most common interventions in the intensive care unit
(ICU). Over the last two decades, numerous studies have investigated methods to improve
outcomes of patients receiving mechanical ventilation. Despite this proliferation of data, a
large, multi-national cohort study found clinical outcomes such as duration of ventilation
and ICU stay have not improved significantly between1998 to 2004.
It is recommended that weaning should be considered as early as possible in the patient
trajectory and spontaneous breathing trials (SBT) attempted, as SBT are the best diagnostic
criteria to determine extubation readiness. The decision of ready to extubate is considered
complex because both delayed and failed extubations are associated with increased ventilator
time and increased mortality. It is shown that dyspnea occurs among nearly half of
ventilator patients and is strongly associated with anxiety and delayed extubation. Between
30-75% of ICU patients report anxiety where dyspnea, impaired communication skills, and
sleep disturbances may be predisposing factors. The assessments of work of breathing and
clinical deterioration are important sub-categories in clinical judgment for determining
weaning tolerance.
There is little evidence whether the patients experiences of work of breathing is
correlating with physicians and nurses. Hence, we suggest the need to evaluate the
interobserver agreement for clinical assessment in weaning.
The main objective of the study is to examine the extent of agreement between patient and
health care provider assessments of work of breathing and the association of agreement with
demographic- and disease-related factors.
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Time Perspective: Prospective
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