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NCT01867853 Clinical Trial

Volume Responsiveness Before SBT Predicts the Outcome of Mechanical Ventilation Weaning in Critically Ill Patients

Weaning Failure Clinical Trial

— weaning  

Official title:
Volume Responsiveness Before Spontaneous Breath Trial Predicts the Outcome of Mechanical Ventilation Weaning in Critically Ill Patients

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01867853
Other study ID # 10286
Secondary ID
Status Completed
Phase N/A
First received May 6, 2013
Last updated June 3, 2013
Start date October 2012
Est. completion date March 2013

Study information
Verified date June 2013
Source Southeast University, China
Contact n/a
Is FDA regulated No
Health authority United States: Food and Drug Administration
Study type Observational [Patient Registry]

Clinical Trial Summary

To evaluate the performance of volume responsiveness in predicting the outcome of mechanical ventilation weaning in critically ill patients.

Description:

82 patients, 61 succeed and 21 failed

Recruitment information / eligibility
Status Completed
Enrollment 82
Est. completion date March 2013
Est. primary completion date March 2013
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- mechanical ventilation

Exclusion Criteria:

- pregnancy or breast-feeding

- tracheostomy at baseline

- myasthenia gravis or acute polyradiculoneuropathy

- end-stage chronic illness

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Device:
• PLR
passive leg raising test was done before and at the end of SBT

Locations
Country Name City State
China Zhongda hospital Nanjing Jiangsu

Sponsors (2)
Lead Sponsor Collaborator
Southeast University, China Zhongda Hospital

Country where clinical trial is conducted

China, 

References & Publications (6)

Eskandar N, Apostolakos MJ. Weaning from mechanical ventilation. Crit Care Clin. 2007 Apr;23(2):263-74, x. — View Citation

MacIntyre N. Discontinuing mechanical ventilatory support. Chest. 2007 Sep;132(3):1049-56. Review. — View Citation

MacIntyre NR, Cook DJ, Ely EW Jr, Epstein SK, Fink JB, Heffner JE, Hess D, Hubmayer RD, Scheinhorn DJ; American College of Chest Physicians; American Association for Respiratory Care; American College of Critical Care Medicine. Evidence-based guidelines f — View Citation

Monnet X, Teboul JL, Richard C. Cardiopulmonary interactions in patients with heart failure. Curr Opin Crit Care. 2007 Feb;13(1):6-11. Review. — View Citation

Monnet X, Teboul JL. Passive leg raising. Intensive Care Med. 2008 Apr;34(4):659-63. doi: 10.1007/s00134-008-0994-y. Epub 2008 Jan 23. — View Citation

Teboul JL, Monnet X. Detecting volume responsiveness and unresponsiveness in intensive care unit patients: two different problems, only one solution. Crit Care. 2009;13(4):175. doi: 10.1186/cc7979. Epub 2009 Aug 10. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary changes of cardiac index 30 minutes No
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