Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

Status Completed

Clinical Trial Summary

Vocal cord paralysis is a common cause of congenital stridor and airway obstruction. In this study we plan to identify the genetic locus of the genes in two extended families who suffer of the disease.

Clinical Trial Description

In a number of families suffering of familial vocal cord paralysis it has previously been shown that the disease is inherited autosomal dominant. In one of the families the gene coding for the disease was located on chromosome 6q16. We will be analyzing 2 extended families with familial vocal cord paralysis to define their genetic defect leading to the disease. All family members will undergo a laryngoscopy to determine the extent of paralysis. For all family members we will isolate DNA and determine their microsatellite polymorphism on chromosome 6q16. If the results are negative we will continue the study and perform a whole genome scan to localize the gene(s) involved. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00382369
Study type	Observational
Source	Hadassah Medical Organization
Contact
Status	Completed
Phase	N/A
Start date	June 1, 2008
Completion date	December 29, 2008

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