Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

Vocal Cord Paralysis Clinical Trial

Official title:

Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00382369
• Other study ID #: VOCALCORD-HMO-CTIL
• Status: Completed
• Phase: N/A
• First received: September 28, 2006
• Last updated: February 23, 2017
• Start date: June 1, 2008
• Est. completion date: December 29, 2008

Study information

• Verified date: February 2017
• Source: Hadassah Medical Organization
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Vocal cord paralysis is a common cause of congenital stridor and airway obstruction. In this study we plan to identify the genetic locus of the genes in two extended families who suffer of the disease.

Description:

In a number of families suffering of familial vocal cord paralysis it has previously been shown that the disease is inherited autosomal dominant. In one of the families the gene coding for the disease was located on chromosome 6q16. We will be analyzing 2 extended families with familial vocal cord paralysis to define their genetic defect leading to the disease. All family members will undergo a laryngoscopy to determine the extent of paralysis. For all family members we will isolate DNA and determine their microsatellite polymorphism on chromosome 6q16. If the results are negative we will continue the study and perform a whole genome scan to localize the gene(s) involved.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: December 29, 2008
• Est. primary completion date: November 17, 2008
• Accepts healthy volunteers: No
• Gender: All
• Age group: 10 Years and older

Eligibility

Inclusion Criteria:

• members of families suffering of familial vocal cord paralysis

Exclusion Criteria:

Related Conditions & MeSH terms

• Paralysis
• Vocal Cord Paralysis

Locations

Country	Name	City	State
Israel	Hadassah-Hebrew University Medical Center, Mt Scopus	Jerusalem

Sponsors (1)

Lead Sponsor	Collaborator
Hadassah Medical Organization

Country where clinical trial is conducted

Israel, 

References & Publications (1)

Manaligod JM, Skaggs J, Smith RJ. Localization of the gene for familial laryngeal abductor paralysis to chromosome 6q16. Arch Otolaryngol Head Neck Surg. 2001 Aug;127(8):913-7. — View Citation