Clinical Trial Details
— Status: Withdrawn
Administrative data
| NCT number |
NCT03143842 |
| Other study ID # |
17-47 |
| Secondary ID |
|
| Status |
Withdrawn |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
April 27, 2017 |
| Est. completion date |
January 25, 2022 |
Study information
| Verified date |
January 2022 |
| Source |
The University of Texas at Dallas |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
The purpose of this study is to investigate whether it is possible to accelerate learning and
improve memory performance in VNS implanted tinnitus participants by pairing VNS with a
verbal paired-associate learning task.
Description:
Associative memory refers to remembering the association between two items, such as a face
and a name or a word in English and the same word in another language. It is not only
important for learning, but it is also one of the first aspects of memory performance that is
impacted by aging and by Alzheimer׳s disease. For decades, neuroscientists have investigated
associative learning and memory and ways to accelerate and enhance associative learning and
memory.
Vagus Nerve Stimulation (VNS) has been delivered to patient populations (e.g. depression,
epilepsy, …) for more than 25 years and there has been some indications that this technique
has effects on cognition, more specifically memory. Studies have investigated VNS as a way to
improve memory performance and it has been shown in some studies to enhance memory in rats
and humans. It has also demonstrated to produce changes in the electrophysiological and
metabolic profile of forebrain and brainstem structures involved in learning and memory.
To investigate whether VNS can accelerate learning and improve associative memory when
learning word pairs, we will investigate the performance of VNS implanted participants on a
Verbal Paired-Associate memory task and compare their performance on the words that were
learned while paired with VNS in contrast to their performance on the words that were learned
while unpaired with VNS and in contrast to their performance on the words that were learned
without VNS (i.e. 3 types/groups of words: paired with VNS, unpaired with VNS and without
VNS) during the first visit and 1 day,1 week and 1 month after their first visit.
